import gc

class MockFrame():
    def grid(self, row, column, sticky):
        pass
mock_frame = MockFrame()

def Button(frame, text=None, fg=None, width=None, command=None, column=None, sticky=None):
    return mock_frame

class Mock():
    pass

self = Mock()
self.buttonRed, self.buttonBlue, self.buttonGreen, self.buttonBlack, self.buttonOpen = (None, )*5

f4 = Mock()
f4.columnconfigure = lambda c, weight: None

ALL = Mock()

button = ["Red", "Blue", "Green", "Black", "Open"]  
color = ["red", "blue", "green", "black", "black"]  
commands = [self.buttonRed, self.buttonBlue, self.buttonGreen,
            self.buttonBlack, self.buttonOpen]  

g = gc.collect()

%%timeit
# Benchmark 1, the original code
for c in range(5):  
    f4.columnconfigure(c, weight=1)
    Button(f4, text=button[c], fg=color[c], width=5,
               command=commands[c]).grid(row=0, column=c, sticky=ALL)

g = gc.collect()

%%timeit
for c, (btn, col, cmd) in enumerate(zip(button, color, commands)):  
    f4.columnconfigure(c, weight=1)
    Button(f4, text=btn, fg=col, width=5, command=cmd). \
               grid(row=0, column=c, sticky=ALL)
    pass

g = gc.collect()

%%timeit
c = 0
for (btn, col, cmd) in zip(button, color, commands):  
    f4.columnconfigure(c, weight=1)
    Button(f4, text=btn, fg=col, width=5, command=cmd). \
               grid(row=0, column=c, sticky=ALL)
    c += 1
    pass

g = gc.collect()

%%timeit
for c, (btn, col, cmd) in enumerate(zip(button, color, commands)):  
    pass

g = gc.collect()

%%timeit
c = 0
for btn, col, cmd in zip(button, color, commands):
    pass
    c += 1