Membrane protiens constitute 30% of all proteins and are targets for 60% of pharmeceuticals on the market. These biomolecules are unique because their structure and function is coupled with the lipid bilayer: a self-assembling nanostructure made from hundreds of lipid types such as phospholipids and cholesterol. The goals of this workshop are to (1) learn common tasks for membrane protein modeling in PyRosetta and (2) give examples of the types of problems one can solve with this framework.